منابع مشابه
The HIV-1 Vaccine Race
There is an urgent need to come up with a vaccine that will curtail the spread of HIV-1. To be successful, the scientific community must work in concert to develop sound strategies based on a deeper understanding of the virus. Significant technological advances are also required to overcome the unique obstacles posed by HIV-1. Some of the challenges we face in this endeavor are discussed here.
متن کاملThe path toward an HIV-1 vaccine
HIV is responsible formillions of deaths around theworld and in the absence of available treatment capable of a cure, only the vaccine can offer protection against this virus. However, and after three decades of research, such a vaccine remains elusive. Here, I attempt to explain themajor challenges on the development of an anti-HIV immunogen, and how the three-dimensional pictures of antibodie...
متن کاملHIV-1 Group M Conserved Elements Vaccine
Recent HIV vaccine designs have sought to block viral escape pathways by compressing antigenic diversity. In light of HIV’s propensity to mutate and thereby to ever ramify viral populations, could it be that providing sufficient protection against global diversity is an insurmountable problem? We propose an alternative HIV-1 vaccine design that deliberately includes viral segments conserved acr...
متن کاملAccelerating HIV-1 Vaccine Efficacy Trials
Despite major advances in HIV-1 therapeutics and prevention strategies, the development of a safe and effective prophylactic HIV-1 vaccine will likely be critical for ending the global HIV-1 epidemic. Yet only four HIV-1 vaccine concepts have been tested for clinical efficacy over the past 30 years. In this Commentary, we describe key hurdles facing the HIV-1 vaccine development field and outli...
متن کاملAn HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses
Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determin...
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ژورنال
عنوان ژورنال: Cell
سال: 2002
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(02)00832-2